@article{86, author = {Michelle Chan and Zachary Smith and Dieter Egli and Aviv Regev and Alexander Meissner}, title = {Mouse ooplasm confers context-specific reprogramming capacity.}, abstract = {

Enucleated oocytes have the distinctive ability to reprogram somatic nuclei back to totipotency. Here, we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer, such as germline-associated promoters, as well as unique limitations that include certain repetitive element classes.

}, year = {2012}, journal = {Nature genetics}, volume = {44}, pages = {978-80}, month = {09/2012}, issn = {1546-1718}, doi = {10.1038/ng.2382}, language = {eng}, }